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Endometrial Preparation for Frozen Embryo Transfer

Doctor advising a couple on endometrial preparation for frozen embryo transfer procedure.

For those exploring assisted reproductive technologies like in vitro fertilization (IVF), the process of frozen embryo transfer (FET) is a significant step towards realizing their dreams of starting a family. In this blog, we’ll explore the intricacies of FET so you can understand more about the procedure and the importance of endometrial preparation.

FET involves transferring cryopreserved embryos created during a previous IVF cycle into the woman’s uterus. This method offers couples flexibility in the timing of conception and can increase the chances of a successful pregnancy. However, the success of FET hinges on the quality of the embryos and also on the receptivity of the uterine lining, known as the endometrium.

What is the Endometrium?

The endometrium is the inner lining of the uterus, a specialized tissue that undergoes dynamic changes during the menstrual cycle in response to hormonal changes.

During the menstrual cycle, the endometrium thickens and becomes highly vascularized in preparation for potential embryo implantation. If conception doesn’t occur, the endometrium lining sheds during menstruation, and the cycle begins anew. However, if fertilization occurs, the embryo implants into the endometrial lining, establishing pregnancy.

The endometrium consists of various cell types, including glandular cells, stromal cells, and immune cells, all of which contribute to its structural integrity and function. It serves as an environment for the developing embryo, providing essential nutrients and support for early growth and development.

In addition to its role in pregnancy, the endometrium also undergoes cyclic changes in response to hormonal signals, which help regulate menstrual bleeding and maintain reproductive health. Abnormalities in the endometrium can lead to conditions such as endometriosis, and adenomyosis, which may affect fertility and pregnancy outcomes.

Understanding the anatomy and physiology of the endometrium is crucial in frozen embryo transfer (FET). Optimizing the endometrial environment through proper preparation ensures the best possible chance of successful FET and pregnancy.

Two Types of Endometrial Preparation

The V Fertility Center at Vejthani Hospital uses two primary methods of endometrial preparation for FET at our ICSI Clinic in Bangkok, Thailand: Natural Cycle FET and Hormone Replacement Therapy (HRT) FET.

Natural Cycle FET

Natural Cycle FET mimics the natural menstrual cycle. Monitoring the woman’s natural cycle, fertility specialists pinpoint the best time for embryo transfer based on the growth of the endometrium and the timing of ovulation. This approach avoids the use of hormonal medications and closely aligns with the body’s natural rhythm, making it an appealing option.

Hormone Replacement (HRT) FET

Hormone Replacement Therapy (HRT) FET involves administering estrogen and progesterone hormones to stimulate and control the menstrual cycle artificially. This method allows for precise regulation of the endometrial thickness and timing of embryo transfer, offering greater predictability and flexibility in scheduling.

The most suitable method for endometrial preparation depends on various factors, including the woman’s menstrual cycle regularity, hormone levels, and medical history. Consulting a fertility specialist is vital to tailor the approach to individual needs and provide the best chances of success.

Visit V Fertility Center

Explaining the importance of endometrial preparation in FET

At V Fertility Center, located at Vejthani Hospital in Bangkok, we have over 15 years of experience in providing comprehensive fertility services. Our dedicated specialists are committed to supporting individuals and couples with compassion, expertise, and cutting-edge treatments. Our world-class technology is accredited by the JCI (Joint Commission International), ensuring our patients receive the most advanced, high-quality treatments.

With a focus on offering personalized care, with a comprehensive range of fertility services and testing, including:

  • Surgical sperm retrieval
  • Oocytes cryopreserve or egg freezing
  • Infertility screening
  • IVF/ICSI treatment
  • Preimplantation genetic diagnosis
  • Intrauterine insemination
  • EmbryoScope Plus

The V Fertility Center is here to guide you every step of the way. Our multidisciplinary approach enables our patients to make informed decisions and achieve their dreams of parenthood. We invite you to visit the V Fertility Center at Vejthani Hospital. Contact us today to schedule an initial consultation.

Article by Dr. Wanakan Singhasena

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