Male infertility significantly affects a couple’s ability to conceive and make up nearly 50% of infertility cases. Sperm quality is a major factor affecting male fertility. It impacts fertilization, embryo development, and pregnancy success rates. For men experiencing high levels of sperm DNA fragmentation, traditional sperm selection methods may not be enough. This is where Magnetic-Activated Cell Sorting (MACS) comes in.
What is MACS Sperm Preparation?
MACS is an advanced sperm preparation technique that improves outcomes in assisted reproductive technologies (ART) like IVF and ICSI. MACS sperm test is a cutting-edge technique used to separate healthy sperm from damaged (apoptotic) sperm. Apoptotic sperm have compromised DNA integrity, which makes them less likely to fertilize an egg successfully. By removing these damaged sperm, MACS helps increase the chances of a successful pregnancy.
How Does MACS Work?
Detection of Apoptotic Sperm
Apoptosis, or programmed cell death, occurs naturally in sperm. However, an excessive number of apoptotic sperm can significantly impact fertility. The MACS sperm selection process identifies these defective sperm using a protein called Annexin V, which binds to phosphatidylserine, a marker found on the membranes of apoptotic sperm. Magnetic beads attached to Annexin V allow the separation process to begin.
Magnetic Separation Process
When the Annexin V-coated sperm sample goes through a magnetic field, the damaged sperm cells bind to the magnetic beads and are retained in the filter, while the healthy, motile sperm pass through. These selected high-quality sperm are then used for fertilization to improve the chances of successful embryo development.
Benefits of MACS Sperm Preparation Test in ART
The MACS sperm selection technique of selecting healthy sperm for fertilization by separating them from sperm that are undergoing apoptosis or programmed cell death has several advantages, including:
Improved Fertilization Rates
MACS sperm test increases the probability of successful fertilization, especially in cases where sperm DNA fragmentation is an issue.
Enhanced Embryo Quality
Since sperm contributes half of the genetic material to an embryo, using only healthy sperm leads to better embryo development, increased implantation potential, and reduced risk of genetic abnormalities.
Reduced Miscarriage Rates
Sperm DNA fragmentation has been linked to recurrent miscarriages. By eliminating apoptotic sperm, MACS sperm selection helps lower the risk of early pregnancy loss and improve overall success rates.
Who Should Consider a MACS Sperm Test?
Men with High Sperm DNA Fragmentation: Men diagnosed with a high sperm DNA fragmentation index (DFI) may benefit from MACS sperm selection to improve their chances of fathering a healthy child.
Couples with Repeated IVF Failures: If previous IVF or ICSI cycles have resulted in failed fertilization or poor embryo quality, the MACS sperm preparation technique may enhance the chances of success.
Cases of Recurrent Miscarriages: Couples who have experienced multiple unexplained miscarriages may find MACS sperm selection helpful in improving embryo viability and reducing pregnancy loss.
Advanced Paternal Age: Older men often have a higher rate of sperm DNA fragmentation. The MACS technique for sperm selection can help ensure that only the healthiest sperm are used and reduce potential complications.
Considerations and Potential Risks of MACS Sperm Selection
Procedure Limitations
While MACS improves sperm quality, it does not address all causes of male infertility. Additional treatments may be needed for other factors like poor sperm motility, genetic issues, and structural abnormalities.
Safety and Efficacy
MACS is a non-invasive technique that does not harm sperm. Scientific studies support its effectiveness in reducing sperm DNA fragmentation and improving ART outcomes. This makes MACS sperm selection a valuable option for couples in preparation for fertility treatments like IVF and ICSI.
Availability of MACS Sperm Selection in Bangkok
VFC Center at Vejthani Hospital is a leading fertility center offering MACS technique for sperm selection. We have a dedicated team of fertility specialists with extensive experience in treating male infertility.
Our fertility lab is equipped with cutting-edge assisted reproductive technologies (ART) for precision in sperm selection and embryo development. The MACS technique for sperm selection in our Bangkok clinic is performed with the latest magnetic cell sorting equipment to increase the likelihood of selecting the healthiest sperm.
We offer a comprehensive range of fertility treatments, including ICSI, IVF, embryo freezing, genetic testing, and egg and sperm freezing. We also provide individualized fertility treatment plans to maximize your chances of success. Our patients benefit from a holistic approach to fertility care with the best options available for their reproductive health.
Book a consultation with the specialists at the VFC Center in Bangkok to learn more about MACS sperm selection.
References:
https://www.bumrungrad.com/en/treatments/magnetic-activated-cell-sorting-macs-for-sperm-selection
https://www.safefertilitygroup.com/en/services/for-men/macs-sperm
https://jetanin.com/services/macs/
The team of specialists in obstetrics and gynecology and reproductive medicine
No Comments
Sorry, the comment form is closed at this time.